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Understanding the relation between laterality and mental disorders

2015-10-24

Ocklenburg2015 Figure 1

Atypical lateralization is observed significantly more often in schizophrenia patients than in the general population, which led several authors to conclude that there is a genetic link between laterality and schizophrenia. However, the molecular genetic evidence for a link between laterality and schizophrenia is weak. In the present article, a multinational team of researchers from the Biopsychology lab and the Bergen fMRI Group in Norway reviewed recent genetic evidence indicates that schizophrenia is not a single disorder but a group of heritable disorders caused by different genotypic networks leading to distinct clinical symptoms. Based on these findings, the researchers suggested a new theoretical framework in which genetic favtors are not mapped on schizophrenia as a whole but on discrete schizophrenia symptoms.

Ocklenburg, S., Güntürkün, O., Hugdahl, K. & Hirnstein, M.,Laterality ad mental disorders in the postgenomic age - A closer lool at schizophrenia and language lateralization, 2015, Neuroscience and Biobehavioral Reviews, 59, 100-110.

Ocklenburg2015 Figure 1

Atypical lateralization is observed significantly more often in schizophrenia patients than in the general population, which led several authors to conclude that there is a genetic link between laterality and schizophrenia. However, the molecular genetic evidence for a link between laterality and schizophrenia is weak. In the present article, a multinational team of researchers from the Biopsychology lab and the Bergen fMRI Group in Norway reviewed recent genetic evidence indicates that schizophrenia is not a single disorder but a group of heritable disorders caused by different genotypic networks leading to distinct clinical symptoms. Based on these findings, the researchers suggested a new theoretical framework in which genetic favtors are not mapped on schizophrenia as a whole but on discrete schizophrenia symptoms.

Ocklenburg, S., Güntürkün, O., Hugdahl, K. & Hirnstein, M.,Laterality ad mental disorders in the postgenomic age - A closer lool at schizophrenia and language lateralization, 2015, Neuroscience and Biobehavioral Reviews, 59, 100-110.