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Left- or right-handed? The molecular basis of handedness

2018-05-17

2018 Schmitz Molecular basis of handedness

Based on latest research output, researchers from the biopsychology lab were invited to contribute a review article to the prestigious journal BIOspektrum, a molecular biologically oriented journal by the German genetics association. Reviewing the current state of research on handedness, the most prominent of functional hemispheric asymmetries, this German article describes research on genetic and epigenetic factors potentially contributing to handedness ontogenesis. Initially thought to be determined by a single gene, molecular genetic studies have shown that handedness is influenced by multiple genes. However, genetic factors can only explain a quarter of the variance in handedness data. Recent research indicates that epigenetic regulation induces asymmetrical gene expression in the embryonic spinal cord, potentially leading to motor asymmetries. An integration of multiple genetic, epigenetic, and environmental factors is essential to fully comprehend handedness ontogenesis.

Schmitz J, Lor S, Güntürkün O, Ocklenburg S. Links- oder Rechtshänder? – Die molekularen Grundlagen der Händigkeit. BIOspektrum. 2018 03: 253-255.

Based on latest research output, researchers from the biopsychology lab were invited to contribute a review article to the prestigious journal BIOspektrum, a molecular biologically oriented journal by the German genetics association. Reviewing the current state of research on handedness, the most prominent of functional hemispheric asymmetries, this German article describes research on genetic and epigenetic factors potentially contributing to handedness ontogenesis. Initially thought to be determined by a single gene, molecular genetic studies have shown that handedness is influenced by multiple genes. However, genetic factors can only explain a quarter of the variance in handedness data. Recent research indicates that epigenetic regulation induces asymmetrical gene expression in the embryonic spinal cord, potentially leading to motor asymmetries. An integration of multiple genetic, epigenetic, and environmental factors is essential to fully comprehend handedness ontogenesis.

Schmitz J, Lor S, Güntürkün O, Ocklenburg S. Links- oder Rechtshänder? – Die molekularen Grundlagen der Händigkeit. BIOspektrum. 2018 03: 253-255.