METLAB BiopsyToolbox







Guest Prof. Dr. S. Mechiel Korte

Ruhr-University Bochum
Fakultät für Psychologie
AE Biopsychologie
D-44780 Bochum, Germany

Room: IB 6-121
Phone: +31 642 71 0991
Fax: +49 234 32 14377


Mechiel Korte is associate professor within the faculty of Pharmaceutical Sciences at Utrecht University, The Netherlands. His research interest can be described as follows: Coming from studying of disparate disorders in different research fields, e.g., Neuroscience, Psychology, Immunology, and Pharmacology, elements that were previously considered to be domains of one discipline are now discovered in the other. There is a rapidly growing amount of evidence demonstrating a strong bidirectional signaling between the immune system and the brain. These neuroimmune-interactions play an important role in many chronic diseases. This is especially true for overlapping disease symptoms caused by chronic inflammation, such as sickness behavior, including pain, fatigue and disturbed cognition, but also feelings of anxiety, impulsivity, compulsivity, and depression. Thus, neuroimmune-interactions play a crucial role in well-being, also known as “The Quality of Life!”



  • Korte-Bouws GAH, Albers E, Voskamp M, Hendriksen H, de Leeuw LR, Güntürkün O, de Roock S, Vastert SJ, Korte SM. Juvenile Arthritis patients suffering from chronic inflammation have increased activity of Both IDO and GTP-CH1 Pathways but decreased BH4 efficacy: implications for well-being, including fatigue, cognitive Impairment, anxiety, and depression. Pharmaceuticals (Basel). 2019 Jan 8;12(1). pii: E9.
  • Korte SM, Prins J, Van den Bergh FS, Oosting RS, Dupree R, Korte-Bouws GA, Westphal KG, Olivier B, Denys DA, Garland A, Güntürkün O. The 5-HT(1A/1B)-receptor agonist eltoprazine increases both catecholamine release in the prefrontal cortex and dopamine release in the nucleus accumbens and decreases motivation for reward and "waiting" impulsivity, but increases "stopping" impulsivity. Eur J Pharmacol. 2017 Jan 5; 794:257-269.
  • Kops MS, Kjaer JB, Güntürkün O, Westphal KG, Korte-Bouws GA, Olivier B, Bolhuis JE, Korte SM. Serotonin release in the caudal nidopallium of adult laying hens genetically selected for high and low feather pecking behavior: an in vivo microdialysis study. Behav Brain Res. 2014 Jul 15; 268:81-7.
  • Korte SM, Koolhaas JM, Wingfield JC, McEwen BS. The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and disease. Neurosci Biobehav Rev. 2005 Feb; 29(1):3-38.

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